San Francisco 49ers · RB RoomRB

#31 Isaac Guerendo

Status  Physically Unable to Perform — PectoralExp  2 yrs NFLAge  26Ht / Wt  6'0" · 225 lbCollege  Louisville; Wisconsin

Depth-chart placement

Current role

RB5

Placement

Depth

Room

Running Back

Experience

YR 3

Last change

Updated 2026-07-29

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RB room context

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Isaac Guerendo holds the RB · Depth spot in San Francisco 49ers’s running back room. Where he sits among the room’s front-line roles:

RB · StarterChristian McCaffreyStarter

RB · BackupJordan JamesBackup

RB · DepthIsaac GuerendoDepth

RB · StarterSincere McCormickStarter

Isaac Guerendo played 14 games in 2025 with a 0% snap share.

Background & career

Isaac Guerendo is a running back for the San Francisco 49ers who was selected in the fourth round (129th overall) of the 2024 NFL Draft. The 6'0", 225-pound back recorded a 4.33-second 40-yard dash at the 2024 NFL Combine, the fastest among running backs. Guerendo played college football at Wisconsin (2018–2022) and Louisville (2023), appearing in 40 games with 231 carries for 1,392 yards and 17 touchdowns. As a rookie in 2024, he appeared in 16 games with 3 starts, registering 84 carries for 420 yards and 4 touchdowns, along with 15 receptions for 152 yards.

Wisconsin2018 – 2022

Louisville2023

49ers2024 — present

College

Louisville; WisconsinDraftRound 4 · No. 129 overall · 2024 · SFHometownClayton, INAlso playsKR1