Osa Odighizuwa holds the RDT · Starter spot in San Francisco 49ers’s defensive tackle room. Where he sits among the room’s front-line roles:

Osa Odighizuwa played 17 games in 2025 with a 63% snap share.

Osa Odighizuwa is a 6'2", 280-pound defensive tackle who attended UCLA, where he appeared in 43 games over five years and recorded 120 tackles and 11.5 sacks. Dallas selected him in the third round (75th overall) of the 2021 NFL Draft. Over five seasons with the Cowboys, he appeared in 84 games with 76 starts, tallying 216 tackles, 17.0 sacks, two forced fumbles, and one pass defensed, plus 14 tackles and 1.0 sack across four postseason games. Odighizuwa signed with the San Francisco 49ers and appeared in 17 games with 13 starts in 2025, recording 44 tackles and 3.5 sacks.

UCLAthrough 2020

Cowboys2021 – 2025

49erspresent

CollegeUCLADraftRound 3 · No. 75 overall · 2021 · DALAcquiredAcquired from Dallas Cowboys · drafted thereHometownPortland, OR