Isaiah McGuire holds the LDE · Backup spot in Cleveland Browns’s edge room. Where he sits among the room’s front-line roles:

Isaiah McGuire played 17 games in 2025 with a 41% snap share.

Isaiah McGuire is a 6'4", 266-pound left defensive end for the Cleveland Browns. The Browns selected him in the fourth round (126th overall) of the 2023 NFL Draft out of Missouri, where he recorded 103 tackles and 16.5 sacks over four years (2019-22), ranking 13th in program history. In 2024, McGuire appeared in 16 games with three starts, posting 34 tackles, three forced fumbles, and 2.5 sacks. He recorded his first career sack on Jan. 7, 2024, and later added a strip-sack of Joe Burrow on Dec. 22, 2024.

Missourithrough 2022

Browns2023 — present

CollegeMissouriDraftRound 4 · No. 126 overall · 2023 · CLEHometownTulsa, OK