San Francisco 49ers

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Bio

Osa Odighizuwa is a 6'2", 280-pound defensive tackle who attended UCLA, where he appeared in 43 games over five years and recorded 120 tackles and 11.5 sacks. Dallas selected him in the third round (75th overall) of the 2021 NFL Draft. Over five seasons with the Cowboys, he appeared in 84 games with 76 starts, tallying 216 tackles, 17.0 sacks, two forced fumbles, and one pass defensed, plus 14 tackles and 1.0 sack across four postseason games. Odighizuwa signed with the San Francisco 49ers and appeared in 17 games with 13 starts in 2025, recording 44 tackles and 3.5 sacks.

Osa Odighizuwa played 17 games in 2025 with a 63% share of defensive snaps.

Player information

Contract

#13 of 217 · DT market by AAV

Production · 2025

Career path