Cameron Sample holds the LDE · Depth spot in San Francisco 49ers’s edge room. Where he sits among the room’s front-line roles:

Cameron Sample played 14 games in 2025 with a 28% snap share.

Cameron Sample, a 6'3" 272-pound defensive end from Snellville, GA, played college football at Tulane, where he recorded 161 tackles and 10.5 sacks across 46 games. The Cincinnati Bengals selected him in 2021 with the 111th overall pick. Over five seasons with Cincinnati (2021–25), Sample appeared in 61 regular-season games with 85 tackles and 7.0 sacks, plus six postseason contests. In 2025, he totaled 17 tackles and 2.0 sacks in 14 games. Sample now enters his sixth season with the San Francisco 49ers.

Tulane2017 – 2020

Bengals2021 – 2025

49erspresent

CollegeTulaneDraftRound 4 · No. 111 overall · 2021 · CINAcquiredAcquired from Cincinnati Bengals · drafted thereHometownSnellville, GA